Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein Networks

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...

Protein-protein Interfaces

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Protein-Protein Interfaces

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

Glomerular Filtration

Glomerular Filtration

The filtration membrane in the renal system is a highly specialized structure essential for filtering blood. It consists of glomerular capillaries and podocytes, forming a selective barrier that permits the passage of water and small solutes while restricting most plasma proteins and blood cells.
Components of the Filtration Membrane
The filtration process involves three key layers: the glomerular endothelial cells, the basement membrane, and the podocyte-formed filtration slits.

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Artery-Like Smooth Muscle Drives Contractile Function in Dural Venous Sinuses.

bioRxiv : the preprint server for biology·2026

Same author

GPIHBP1 on oligodendrocytes binds lipoprotein lipase within the human brain.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Efficient sampling of liver tissue for histological analysis of rodent MASLD/MASH models.

Histology and histopathology·2026

Same author

Therapeutic efficacy, biomarker signatures, and translatability of semaglutide in the liver biopsy-confirmed GAN DIO-MASH mouse model.

American journal of physiology. Gastrointestinal and liver physiology·2026

Same author

FGFR signaling establishes spatial gradients of secretory cell identities along the airway proximal-distal axis.

Nature communications·2026

Same author

Loss of meningeal lymphatic endothelial cells results in formation of a newly forming vascular network with scavenging function.

Development (Cambridge, England)·2026

Search research articles

Related Experiment Video

Updated: Jul 9, 2026

mRNA Interactome Capture from Plant Protoplasts

mRNA Interactome Capture from Plant Protoplasts

Published on: July 28, 2017

The glomerular transcriptome and a predicted protein-protein interaction network.

Liqun He¹, Ying Sun, Minoru Takemoto

¹Division of Matrix Biology, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, SE 171 77, Stockholm, Sweden.

Journal of the American Society of Nephrology : JASN

|November 23, 2007

Summary

This summary is machine-generated.

Researchers created a comprehensive gene list for the kidney glomerulus and a protein interaction network called GlomNet. This advances understanding of glomerular molecular composition and signaling in health and disease.

Related Experiment Videos

Last Updated: Jul 9, 2026

mRNA Interactome Capture from Plant Protoplasts

mRNA Interactome Capture from Plant Protoplasts

Published on: July 28, 2017

Area of Science:

Nephrology
Genomics
Systems Biology

Background:

Understanding the kidney glomerulus's molecular makeup is crucial for diagnosing and treating kidney diseases.
Existing transcriptional profiles are fragmented, limiting a holistic view of glomerular biology.

Purpose of the Study:

To create a comprehensive catalogue of glomerulus-enriched genes.
To build a predicted protein-protein interaction network for the glomerulus (GlomNet).
To integrate diverse glomerular transcriptional data for a unified understanding.

Main Methods:

Meta-analysis of five distinct glomerular transcriptional profiling methodologies from mouse and human samples.
Generation of a combined gene catalogue.
Construction of a predicted protein-protein interaction network (GlomNet).

Main Results:

A comprehensive catalogue of glomerulus-enriched genes was successfully generated.
The GlomNet protein-protein interaction network was constructed, offering insights into glomerular signaling.
This integrated approach provides the most complete molecular picture of the glomerulus to date.

Conclusions:

The study provides an unprecedentedly comprehensive view of glomerular molecular composition.
GlomNet offers a valuable tool for understanding glomerular signaling networks in development, function, and disease.
This integrative systems biology approach enhances the study of kidney glomerulus biology.