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Updated: Jul 9, 2026

Measuring Psoriasis Severity at Home
Published on: March 1, 2024
Poor reporting of quality of life outcomes in dermatology randomized controlled clinical trials
Laurence Le Cleach1, Olivier Chassany, Annabelle Levy
1Service de Dermatologie, Centre Hospitalier Sud Francilien, Corbeil-Essonnes, France. laurence.lecleach@free.fr
Background:
Because many dermatological diseases are chronic but not life-threatening, consideration of their impact on health-related quality of life (QOL) seems essential.
Objective:
To analyze the use of QOL as an evaluation endpoint in randomized clinical trials concerning skin diseases.
Methods:
Studies identified by computerized search of 3 bibliographical databases were selected, and their data on QOL as an evaluation endpoint were collected and analyzed.
Results:
Among the 67 studies retained, 87% did not adequately describe the questionnaires; 75% did not address handling of missing data; 95% did not calculate the number of subjects needed to obtain the desired statistical power; 95% did not disclose before-and-after results as means of overall scores and each dimension.
Conclusion:
Our analysis highlighted methodological weaknesses in the use of QOL questionnaire and poor reporting of QOL outcomes in randomized clinical trials.
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