Atypical acute graft-versus-host disease

Area of Science:

• Hematology
• Immunology
• Dermatology

Background:

• Acute graft-versus-host disease (GVHD) is a serious complication following allogeneic bone marrow transplantation.
• Cutaneous manifestations are common and often represent the initial signs of acute GVHD.

Observation:

• This case report details a patient with acute GVHD exhibiting unusual clinical and histopathological features.
• Clinically, the presentation was limited to two erythematous nodules.

Findings:

• Histopathological examination revealed abrupt follicular wall necrosis, a rare finding in acute GVHD.
• The combination of these specific clinical and pathological findings is uncommon.

Implications:

• Recognizing rare dermatologic presentations of acute GVHD is vital for prompt diagnosis and management.
• Understanding these unique findings can improve diagnostic accuracy and patient outcomes in transplantation medicine.