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Large-cell neuroendocrine carcinoma of the skin, with lymphoid stroma
Masako Kasami1, Kouji Muramatsu, Kazuhiro Kawahata
1Department of Pathology, Shizuoka Cancer Center Hospital and Research Institute, Shimonagakubo, Nagaizumi-cho, Sunto-gun, Japan. m.kasami@scchr.jp
Abstract:
We report two cases of a large-cell neuroendocrine carcinoma of the skin as a distinct histological category. The patients are a 63-year-old woman with a 7-mm reddish round nodule on her nose for 4 months, and a 95-year-old man with several hemorrhagic nodules on the external ear for 28 months. The first patient had two positive sentinel lymph nodes. The tumors from both patients consisted of islands of pleomorphic large cells within a lymphoid stroma.
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