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Antigen-Capture Enzyme-Linked Immunosorbent Assay for Specific Detection of Mycoplasma pneumoniae
Published on: February 24, 2023
[Optic neuritis attributable to Mycoplasma pneumoniae]
E Sagui1, E Chazalon, M Bregigeon
1Service de Neurologie, Hôpital d'Instruction des Armées Laveran, Marseille. emmanuel.sagui@laposte.net
Abstract:
Optic neuritis (ON) is an inflammatory disease whose etiology remains obscure. We report a case of ON attributable to Mycoplasma pneumoniae (MP). A 26-year-old man presented a sudden onset bilateral loss of visual acuity, without any history of pulmonary or ear-nose-throat infection. Diagnosis of optic neuritis was made on the basis of visual field loss, though optic disks and visual evoked potentials were normal. Color vision could not be assessed due to a congenital dyschromatopsia. The neurological examination was normal. On magnetic resonance imaging, there was no enhancement or enlargement of optic nerves, but a demyelinating lesion of the cervical spinal cord. Lumbar puncture revealed lymphocytic meningitis with 60 white blood cells, all of them being lymphocytes. Oligoclonal bands were presents in the CSF. With no evidence of any other infection or auto-immune disease, the diagnosis of Mycoplasma pneumoniae infection was established due to the presence of Mycoplasma pneumoniae specific IgM antibodies. Outcome was quite favorable within three months without treatment. Neurological symptoms--encephalitis, meningitis, polyradiculitis, or more rarely ON or cerebella ataxia--are the main extra pulmonary manifestations of Mycoplasma pneumoniae infection. Search for anti-Mycoplasma pneumoniae IgM antibodies should be performed routinely when On is diagnosed.
Insights
Optic neuritis, an inflammatory eye condition, can be caused by Mycoplasma pneumoniae infection. Early detection through antibody testing is recommended for Mycoplasma pneumoniae-related optic neuritis.
Area of Science:
- Neurology
- Ophthalmology
- Infectious Diseases
Background:
- Optic neuritis (ON) is an inflammatory condition of the optic nerve with often unknown causes.
- Extra-pulmonary manifestations of Mycoplasma pneumoniae (MP) infection can include neurological conditions.
Observation:
- A 26-year-old man presented with sudden bilateral vision loss, diagnosed as ON.
- Cervical spinal cord demyelination and lymphocytic meningitis were observed.
- Mycoplasma pneumoniae specific IgM antibodies were detected, confirming MP infection.
Findings:
- The case highlights a rare presentation of ON linked to Mycoplasma pneumoniae infection.
- Cerebrospinal fluid analysis revealed lymphocytic meningitis with oligoclonal bands.
- Magnetic resonance imaging showed a demyelinating lesion in the cervical spinal cord.
Implications:
- Routine screening for anti-Mycoplasma pneumoniae IgM antibodies is suggested for patients diagnosed with ON.
- This finding expands the understanding of Mycoplasma pneumoniae's neurological impact.
- Prompt diagnosis and potential treatment can lead to favorable outcomes in MP-associated neurological conditions.
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