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[Bacterial biofilms].

A G Beule1, W Hosemann

  • 1Klinik und Poliklinik für Hals-Nasen-Ohrenheilkunde, Kopf- und Halschirurgie der Universität Greifswald, Walther-Rathenau-Strasse 43-45, Greifswald. achim.beule@uni-greifswald.de

Laryngo- Rhino- Otologie
|November 23, 2007
PubMed
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Biofilms cause most infections, particularly in Otorhinolaryngology (ENT) diseases like chronic tonsillitis and sinusitis. Current antibiotic treatments are often ineffective, necessitating new therapeutic strategies for these biofilm-associated conditions.

Area of Science:

  • Microbiology and Infectious Diseases
  • Otorhinolaryngology
  • Biomaterials Science

Context:

  • Biofilms are implicated in 65% of all infections.
  • Many common Otorhinolaryngology (ENT) conditions, including chronic tonsillitis, chronic sinusitis, otitis media with effusion, and cholesteatomas, exhibit characteristics of biofilm-associated diseases.
  • ENT procedures frequently involve implanting devices in areas prone to biofilm formation, such as the trachea, middle ear, and paranasal sinuses.

Purpose:

  • To summarize the relevant characteristics and development of biofilms.
  • To present clinical knowledge of Otorhinolaryngology diseases linked to biofilms.
  • To discuss current and future therapeutic strategies for biofilm-associated infections in ENT.

Summary:

  • This review details the nature of biofilms and their role in persistent infections.

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  • It highlights how conditions like chronic sinusitis and otitis media are often recalcitrant due to biofilms, resisting standard antibiotic therapies.
  • The discussion extends to implants used in ENT, which are also susceptible to biofilm colonization.
  • Impact:

    • Provides a comprehensive overview of biofilm challenges in Otorhinolaryngology.
    • Emphasizes the limitations of current antibiotic treatments against biofilms.
    • Outlines the need for novel therapeutic approaches to effectively manage biofilm-associated diseases and improve patient outcomes in ENT care.