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PBX proteins: much more than Hox cofactors
Audrey Laurent1, Réjane Bihan, Francis Omilli
1IGDR, UMR CNRS 6061, Génétique et Développement, IFR 140, Faculté de Médecine, Université de Rennes 1, France.
The International Journal of Developmental Biology
|November 23, 2007
Summary
Pre-B cell leukaemia transcription factors (PBXs) are key developmental regulators. This review highlights their diverse partnerships beyond Hox proteins, emphasizing their role in integrating signals for gene expression during development.
Area of Science:
- Developmental biology
- Molecular biology
- Genetics
Background:
- Pre-B cell leukaemia transcription factors (PBXs) were initially identified as Hox cofactors.
- Their function extends beyond Hox or homeodomain protein partnerships.
- PBXs are crucial for various developmental pathways, including Hox-independent mechanisms.
Purpose of the Study:
- To review known PBX partnerships.
- To position PBXs as central developmental factors.
- To elucidate the role of PBXs in integrating transduction signals for gene regulation.
Main Methods:
- Literature review of existing research on PBX factors.
- Analysis of studies investigating PBX interactions and functions.
- Synthesis of evidence regarding PBX roles in developmental pathways.
Main Results:
- PBX proteins engage in diverse molecular partnerships.
- PBXs are involved in multiple developmental processes.
- Evidence supports PBX involvement in Hox-independent pathways.
Conclusions:
- PBXs are versatile regulators essential for development.
- PBXs integrate cellular signals to control gene expression programs.
- Understanding PBX partnerships is key to deciphering developmental regulation.
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