Biochemical diagnostics of bone metastases

The skeleton is a frequent localization of cancer metastases. The method of choice in their diagnostics is scintigraphy, but at high sensitivity, it is characterized by limited diagnostic specificity. Discussed are the possibilities of using the examination of some tumor markers as well as biochemical factors of the resorption and bone formation process in bone metastases diagnostics. At the present stage, it can be found that the studies of such factors introduce a number of additional significant information, but they cannot fully replace bone scan.