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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

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Published on: August 18, 2014

Therapeutic receptor targets for lower urinary tract dysfunction.

Naoki Yoshimura¹, Yasuhiro Kaiho, Minoru Miyazato

¹Department of Urology, University of Pittsburgh School of Medicine, Suite 700 Kaufmann Medical Building, 3471 Fifth Avenue, Pittsburgh, PA 15213, USA. nyos@pitt.edu

Naunyn-Schmiedeberg'S Archives of Pharmacology

|November 24, 2007

Summary

This study explores lower urinary tract function and dysfunction, identifying therapeutic targets for overactive bladder and stress urinary incontinence. It highlights the urothelium

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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Published on: August 14, 2019

Area of Science:

Neuroscience
Urology
Pharmacology

Background:

Lower urinary tract function relies on smooth and striated muscle coordination for urine storage and voiding.
Dysfunction can arise from nervous system injuries, diseases, drugs, or peripheral organ disorders.
Overactive bladder (OAB) and stress urinary incontinence (SUI) represent common lower urinary tract dysfunctions.

Purpose of the Study:

To review the integrated neural control of the lower urinary tract.
To identify potential therapeutic targets for managing overactive bladder (OAB).
To explore pharmacotherapeutic strategies for stress urinary incontinence (SUI).

Main Methods:

Review of scientific literature on lower urinary tract physiology and pathophysiology.
Analysis of the role of the urothelium in sensory signaling and OAB pathogenesis.
Examination of neural pathways and receptor targets for OAB and SUI pharmacotherapy.

Main Results:

The urothelium possesses sensory and signaling properties, with altered expression/sensitivity contributing to OAB.
Therapeutic targets for OAB include urothelial receptors, afferent pathways, and detrusor muscles.
Pharmacotherapies for SUI can target spinal cord and urethral sphincter receptors to enhance continence reflexes.

Conclusions:

Modulating urothelial-sensory pathways and bladder smooth muscle activity shows promise for OAB treatment.
Targeting specific receptors in the spinal cord and urethral sphincter may improve SUI management.
A comprehensive understanding of lower urinary tract neurobiology is crucial for developing effective therapies.