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Aspirin-sensitive asthma: recent advances in management
1Department of Allergy and Clinical Immunology, Ajou University Schoolof Medicine, Suwon, Korea. hspark@madang.ajou.ac.kr
Summary
Aspirin-sensitive asthma involves severe inflammation and requires avoiding aspirin and NSAIDs. Aspirin desensitization can improve nasal symptoms in these patients.
Area of Science:
- Allergy and Immunology
- Pulmonology
- Pharmacology
Background:
- Aspirin-sensitive asthma (ASA) presents with eosinophilic inflammation in nasal and bronchial tissues.
- It commonly affects non-atopic, middle-aged females with chronic rhino-sinusitis and/or nasal polyps.
Purpose of the Study:
- To review the diagnostic and therapeutic strategies for aspirin-sensitive asthma.
- To highlight the importance of avoiding aspirin and NSAIDs and discuss pharmacotherapy.
Main Methods:
- Diagnostic evaluation using the lysine-aspirin bronchoprovocation test.
- Review of pharmacotherapeutic principles including anti-inflammatory therapy.
Main Results:
- Confirmation of ASA sensitivity necessitates strict avoidance of aspirin and NSAIDs to prevent adverse reactions.
- Corticosteroids are primary treatment; anti-leukotriene agents may be used.
- Aspirin desensitization can alleviate inflammatory mucosal disease, especially in nasal passages.
Conclusions:
- Complete avoidance of aspirin and NSAIDs is critical for patients with confirmed ASA sensitivity.
- Step-wise anti-inflammatory therapy, primarily with corticosteroids, forms the basis of management.
- Aspirin desensitization offers a potential therapeutic option for managing symptoms in ASA-sensitive asthma.
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