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Updated: Jul 9, 2026

Quantification of Autoreactive Antibodies in Mice upon Experimental Autoimmune Encephalomyelitis
Published on: December 1, 2023
Anti-interleukin-12 antibody: potential role in preventing relapses of multiple sclerosis
1Department of Neurology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283, USA.
Abstract:
Multiple sclerosis is an inflammatory demyelinating disorder of the central nervous system. Immunological evidence from patients with multiple sclerosis and experimental models suggests that the cytokine interleukin-12 (IL-12) plays an important role in the pathogenesis of inflammatory demyelination. In experimental autoimmune encephalomyelitis, an animal model of multiple sclerosis, antibodies that block IL-12 can prevent relapses of the disease. Anti-IL-12 antibodies present a novel approach for preventing relapses in multiple sclerosis.
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