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Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide generation. 
Oral Drug Delivery Systems: Delayed-Release Systems01:11

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...

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Related Experiment Video

Updated: Jul 9, 2026

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
12:37

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Published on: September 11, 2012

Delayed-release Multi Matrix System (MMX) mesalazine: in ulcerative colitis.

Paul L McCormack1, Dean M Robinson, Caroline M Perry

  • 1Wolters Kluwer Health | Adis, Auckland, New Zealand, an editorial office of Wolters Kluwer Health, Conshohocken, Pennsylvania, USA. demail@adis.co.nz

Drugs
|November 24, 2007
PubMed
Summary

Multi Matrix System (MMX) mesalazine effectively treats ulcerative colitis by delivering medication throughout the colon. Clinical trials show MMX mesalazine significantly improves remission rates compared to placebo.

Related Experiment Videos

Last Updated: Jul 9, 2026

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)
12:37

Modeling Colitis-Associated Cancer with Azoxymethane (AOM) and Dextran Sulfate Sodium (DSS)

Published on: September 11, 2012

Area of Science:

  • Gastroenterology
  • Pharmacology
  • Inflammatory Bowel Disease

Background:

  • Ulcerative colitis (UC) is a chronic inflammatory bowel disease affecting the colon.
  • Mesalazine is a key treatment for UC, acting locally on the colonic mucosa.
  • The Multi Matrix System (MMX) is designed for targeted delivery of mesalazine throughout the colon.

Purpose of the Study:

  • To evaluate the efficacy and safety of MMX mesalazine in patients with active, mild to moderate ulcerative colitis.
  • To compare MMX mesalazine's remission rates against placebo and non-MMX delayed-release mesalazine.

Main Methods:

  • Two Phase III clinical trials were conducted involving a total of 603 patients with active UC.
  • Patients received either MMX mesalazine (2.4 or 4.8 g/day), non-MMX delayed-release mesalazine, or placebo for 8 weeks.
  • Clinical and endoscopic remission were the primary efficacy endpoints.

Main Results:

  • Significantly higher clinical and endoscopic remission rates were observed with MMX mesalazine (2.4 and 4.8 g/day) compared to placebo in both trials (p < 0.01).
  • MMX mesalazine showed superior efficacy to placebo, with remission rates of 29-41.2% versus 13-22.1%.
  • Non-MMX delayed-release mesalazine did not demonstrate a significant difference from placebo in remission rates.

Conclusions:

  • MMX mesalazine is an effective treatment for active, mild to moderate ulcerative colitis, demonstrating superior efficacy over placebo.
  • The MMX formulation facilitates colonic drug delivery, leading to improved therapeutic outcomes.
  • MMX mesalazine was generally well-tolerated, with a similar incidence of adverse events to placebo, though rare serious events like pancreatitis were noted.