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Updated: Jul 9, 2026

Murine Model of Epicutaneously-Induced Immunomodulation
Published on: June 24, 2025
Epidermal chemokines and modulation by antihistamines, antibiotics and antifungals
Yoshiki Tokura1, Miwa Kobayashi, Kenji Kabashima
1Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu, Japan. tokura@med.uoeh-u.ac.jp
Abstract:
Growing evidence has demonstrated that chemokines released from epidermal cells control inflammatory skin diseases. Keratinocytes elaborate both Th1- and Th2-associated chemokines, although the former is more abundantly produced than the latter. Downmodulation of keratinocyte production of chemokines is one of the therapeutic approaches for cutaneous inflammatory disorders. Recent observations have shown that keratinocyte chemokine production can be modulated by well-used drugs, including antihistamines, antibiotics and antifungals. Utilization of the beneficial side effects of these drugs may by clinically valuable.
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