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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma

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Related Experiment Videos

Atopic dermatitis and asthma.

Elena Galli1, Simona Gianni, Giovanni Auricchio

  • 1Research Center, AFaR, S. Pietro Hospital, Fatebenefratelli, Roma, Italy. galli.elena@fbfrm.it

Allergy and Asthma Proceedings
|November 24, 2007
PubMed
Summary

Atopic dermatitis (AD) in children may be an early sign for developing respiratory allergies like asthma. Managing AD effectively could potentially prevent or reduce the severity of these later allergic conditions.

Related Experiment Videos

Area of Science:

  • Pediatric Dermatology
  • Allergology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a prevalent chronic inflammatory skin condition in children, often linked to respiratory allergies.
  • The increasing incidence of AD and allergic diseases poses a significant healthcare burden.
  • AD is hypothesized as an 'entry point' for other allergic conditions, including asthma.

Purpose of the Study:

  • To investigate the natural progression of atopic dermatitis (AD) in children.
  • To understand the potential link between childhood AD and the development of subsequent allergic diseases, particularly asthma.
  • To explore the concept of the 'atopic march' from AD to respiratory allergies.

Main Methods:

  • Review of existing longitudinal studies examining the course of AD in childhood.
  • Analysis of genetic and epidemiological data related to AD and asthma.
  • Evaluation of the evidence for the 'atopic march' phenomenon.

Main Results:

  • Evidence suggests a common genetic and pathogenic basis for AD and asthma.
  • Longitudinal studies indicate a progression from AD to allergic rhinitis and asthma (the 'atopic march').
  • Limited prospective birth cohort studies with long follow-up exist, hindering a full understanding of AD's natural course.

Conclusions:

  • Effective management of childhood AD may prevent or mitigate the development of respiratory allergies.
  • Further prospective research is needed to fully elucidate the natural history of AD and its association with asthma.
  • The relationship between AD and asthma warrants further investigation, considering possibilities of progression or co-occurrence within a syndrome.