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[Multiple eruptive dermatofibromas in 2 patients infected with the human immunodeficiency virus]

C García-Millán1, I Aldanondo, M Fernández-Lorente

  • 1Servicio de Dermatología, Hospital Universitario Ramón y Cajal, Madrid, España. cgmillan@gmail.com

Actas Dermo-Sifiliograficas
|November 24, 2007
PubMed

Insights

Multiple eruptive dermatofibromas, a rare skin condition, often indicate underlying autoimmune diseases or immunodeficiency. These cases highlight the potential for eruptive dermatofibromas to signal early HIV infection.

Area of Science:

  • Dermatology
  • Infectious Diseases
  • Immunology

Background:

  • Multiple eruptive dermatofibromas (MED) are characterized by the sudden onset of numerous dermatofibromas.
  • Diagnosis typically requires 5-15 lesions appearing within months, though definitions vary.
  • MED is often associated with underlying conditions, including autoimmune disorders and immunodeficiency.

Observation:

  • This report details two cases of MED in patients with Human Immunodeficiency Virus (HIV) infection.
  • One patient was diagnosed with HIV subsequent to the presentation of MED.
  • The skin lesions appeared rapidly over a short period.

Findings:

  • The two cases demonstrate a strong association between MED and HIV infection.
  • MED can manifest in individuals with previously undiagnosed HIV.
  • The appearance of multiple dermatofibromas may serve as an early cutaneous sign of immunosuppression.

Implications:

  • The presentation of MED could prompt earlier diagnosis of HIV infection in at-risk individuals.
  • MED may serve as a clinical indicator for underlying immunodepression, prompting further investigation.
  • Increased awareness of this association can improve diagnostic pathways for both dermatological and systemic conditions.

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