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Influence of hypersulfated lactobionic acid amides on tissue plasminogen activator release
H P Klöcking1, A Hoffmann, J Fareed
1Institute of Pharmacology and Toxicology, Medical Academy Erfurt, Germany.
Seminars in Thrombosis and Hemostasis
|October 1, 1991
Abstract:
Under our experimental conditions, the sulfated bis-lactobionic acid amide, LW 10079, showed the strongest t-PA-releasing effect in the isolated perfused pig ear. In rats the sulfated bis-lactobionic acid amide LW 10121 was the most potent compound in acute t-PA release. In both experiments the bis-lactobionic acid amide LW 10082 did not work as a releaser of t-PA. Therefore in the case of LW 10082, the activation of the fibrinolytic pathway as a possible mechanism of its antithrombotic effect can be excluded.