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Seroepidemiology and genotypes of hepatitis C virus in Thailand

Srunthron Sunanchaikarn1, Apiradee Theamboonlers, Voranush Chongsrisawat

  • 1Center of Excellence in Viral Hepatitis Research, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Asian Pacific Journal of Allergy and Immunology
|November 27, 2007
PubMed

Insights

Hepatitis C virus (HCV) genotype prevalence in Thailand was surveyed in 2004. Genotype 3a was most common, followed by 1b and 6, crucial data for public health strategies.

Area of Science:

  • Virology
  • Epidemiology
  • Public Health

Background:

  • Hepatitis C virus (HCV) is a major global health concern.
  • HCV exhibits significant genetic diversity with six major genotypes.
  • Understanding HCV genotype distribution is vital for effective treatment and prevention strategies.

Purpose of the Study:

  • To determine the seroprevalence and genotype distribution of HCV in Thailand.
  • To provide updated epidemiological data for public health surveillance.

Main Methods:

  • An epidemiological survey was conducted in 2004 across four Thai provinces.
  • Serum samples from 5,825 individuals aged 2-60 years were tested for anti-HCV antibodies using ELISA.
  • Positive samples were further analyzed by RT-PCR and core region sequencing for genotyping.

Main Results:

  • The overall anti-HCV seroprevalence was 2.15% (125/5,825).
  • RT-PCR confirmed 58% (58/100) of anti-HCV positive samples.
  • Sequencing identified genotypes 1a, 1b, 2a, 2c, 3a, 3b, and 6, with genotype 3a being the most prevalent (51.1%).

Conclusions:

  • HCV genotype 3a is the predominant strain in Thailand.
  • The findings highlight the importance of regional genotype surveillance for guiding public health interventions against HCV.

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