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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...
Herpes01:28

Herpes

Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Related Experiment Videos

Eruptive lichen planus in a child.

Hagen Ott1, Jorge Frank, Pamela Poblete-Gutiérrez

  • 1Department of Dermatology and Allergology, University Hospital of the RWTH, Aachen, Germany.

Pediatric Dermatology
|November 27, 2007
PubMed
Summary

This study reports a rare case of exanthematous lichen planus in a 7-year-old child. Topical corticosteroid ointment effectively treated the widespread skin lesions without systemic side effects.

Area of Science:

  • Dermatology
  • Pediatric Dermatology
  • Inflammatory Diseases

Background:

  • Lichen planus is a chronic inflammatory condition affecting skin and mucous membranes, typically in adults.
  • Pediatric cases are rare, and exanthematous presentations are even less common.
  • Understanding varied clinical presentations is crucial for accurate diagnosis and management.

Observation:

  • A 7-year-old boy presented with rapidly developing, itchy skin lesions on his trunk and extremities.
  • Clinical examination revealed multiple white-grayish papules and plaques.
  • No history of drug intake, infection, or vaccination preceded the onset; scalp, mucous membranes, and nails were unaffected.

Findings:

  • Histologic examination confirmed typical findings of lichen planus.

Related Experiment Videos

  • The patient received topical corticosteroid ointment therapy.
  • Complete healing of skin lesions occurred within 4 weeks.
  • Implications:

    • This case represents the first documented instance of exanthematous lichen planus in childhood successfully treated with topical corticosteroids alone.
    • Localized topical treatment can effectively manage generalized lichen planus in children, avoiding potential systemic therapy side effects.
    • Highlights the efficacy of conservative treatment for pediatric lichen planus variants.