[The prognostic assessment of patient survival in chronic myeloleukemia]

The prognostic significance of the clinicohematological and kinetic characteristics was analyzed in patients suffering from chronic myeloleukemia with the aid of computerized methods of linear and nonlinear regression (Cox's model). New predictors not previously used in patients with chronic myeloleukemia are offered: the ratio of variation of the integral optic density of mature neutrophil nuclei stained with methylene blue and the general marker index (GMI) of circulating granulocytes with 3H-thymidine in vitro. The relationship between the GMI and the survival when estimated according to chi 2 in Cox's model surpassed 3-11-fold that for the clinicohematological characteristics. A regression equation was derived, allowing the probable patient's survival (in months) to be predicted.