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Updated: Jul 9, 2026

Oncogenic Gene Fusion Detection Using Anchored Multiplex Polymerase Chain Reaction Followed by Next Generation Sequencing
Published on: July 5, 2019
Confirmation of a novel recurrent association: BCR-ABL t(9;22) and t(19;21)
Stéphanie Struski1, Catherine Hélias, Carine Gervais
1Institute of Hematology, Faculty of Medicine, 4 rue Kirschleger, 67000 Strasbourg, France. Stephanie.struski@chru-strasbourg.fr
Abstract:
Association of a t(9;22)(q34;q11), BCR/ABL-positive, with a dic(19;21)(p13;p13) has been described in acute lymphoblastic leukemia in relapse, raising the question of whether this association is recurrent. Described here are two cases, one of myeloproliferative disease and one of acute lymphoblastic leukemia, both presenting a masked t(9;22) and t(19;21). Chromosomal rearrangements were ascertained by fluorescence in situ hybridization (FISH) using locus-specific probes, multicolor FISH, and bacterial artificial chromosome array. These additional observations suggest a nonrandom association.
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