Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

MAPK Signaling Cascades01:07

MAPK Signaling Cascades

Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
Notch Signaling Pathway03:14

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...
cAMP-dependent Protein Kinase Pathways01:25

cAMP-dependent Protein Kinase Pathways

Cyclic Adenosine Monophosphate (cAMP) is an essential second messenger that activates protein kinase A (PKA) and regulates various biological processes. A single epinephrine molecule binds to GPCR and activates several heterotrimeric G proteins, each stimulating multiple adenylyl cyclase, amplifying the signal, and synthesizing large numbers of cAMP molecules. Small changes in cAMP concentration affect PKA activity. The binding of four cAMP molecules induces a conformational change in PKA,...
Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Comparative studies on zirconia and graphene composites obtained by one-step and stepwise electrodeposition for deoxyribonucleic acid sensing.

Analytica chimica acta·2013
Same author

Genetic etiology study of the non-syndromic deafness in Chinese Hans by targeted next-generation sequencing.

Orphanet journal of rare diseases·2013
Same author

Observation of the sixth polymorph of BiB3O6: in situ high-pressure Raman spectroscopy and synchrotron X-ray diffraction studies on the β-polymorph.

Inorganic chemistry·2013
Same author

Identification of a linear B-cell epitope within the Bluetongue virus serotype 8 NS2 protein using a phage-displayed random peptide library.

Veterinary immunology and immunopathology·2013
Same author

MicroRNA-214 provokes cardiac hypertrophy via repression of EZH2.

Biochemical and biophysical research communications·2013
Same author

The prevalence of thyroid nodules and its relationship with metabolic parameters in a Chinese community-based population aged over 40 years.

Endocrine·2013

Related Experiment Video

Updated: Jul 9, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

The JNK pathway and neuronal migration.

Yiming Sun1, Tao Yang, Zhiheng Xu

  • 1Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China.

Journal of Genetics and Genomics = Yi Chuan Xue Bao
|November 27, 2007
PubMed
Summary
This summary is machine-generated.

The c-Jun N-terminal kinases (JNKs) pathway is crucial for neuronal cell death but also significantly impacts neuronal migration. This review highlights JNK

More Related Videos

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
11:32

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

Related Experiment Videos

Last Updated: Jul 9, 2026

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons
09:50

Ex Utero Electroporation and Organotypic Slice Cultures of Embryonic Mouse Brains for Live-Imaging of Migrating GABAergic Interneurons

Published on: April 20, 2018

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro
11:32

Nucleofection of Rodent Neuroblasts to Study Neuroblast Migration In vitro

Published on: November 12, 2013

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain
10:25

Time-lapse Imaging of Neuroblast Migration in Acute Slices of the Adult Mouse Forebrain

Published on: September 12, 2012

Area of Science:

  • Neuroscience
  • Cell Biology
  • Molecular Biology

Background:

  • c-Jun N-terminal kinases (JNKs) are key regulators in the nervous system.
  • JNK signaling is implicated in neuronal cell death following stress or injury.
  • Emerging evidence suggests a role for JNK in neuronal migration.

Purpose of the Study:

  • To introduce the JNK signaling pathway.
  • To emphasize the role of JNK in neuronal migration.
  • To consolidate current understanding of JNK's function in nervous system development and disease.

Main Methods:

  • Literature review of studies on JNK signaling.
  • Analysis of research investigating JNK's role in neuronal migration.
  • Synthesis of findings on JNK pathway mechanisms.

Main Results:

  • JNK pathway is involved in diverse physiological and pathological processes.
  • JNK signaling is a critical mediator of neuronal death.
  • JNK pathway plays a significant role in guiding neuronal migration.

Conclusions:

  • The JNK pathway is a multifaceted signaling system with implications beyond cell death.
  • Understanding JNK's role in neuronal migration is vital for nervous system development and repair.
  • Further research into JNK signaling in neuronal migration could reveal therapeutic targets.