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Related Concept Videos

Anthelminthic Agents01:15

Anthelminthic Agents

Anthelmintic drugs differ significantly from antiparasitic therapies targeting protozoa, primarily due to differences in parasite biology. Whereas most protozoal treatments act on proliferating cells, anthelmintics are typically directed against mature, nonproliferative helminths. The therapeutic approach considers the helminth's reliance on neuromuscular coordination, glucose metabolism, and microtubular integrity for survival, reproduction, and localization within the host. Most anthelmintics...
Antiprotozoal Agents01:21

Antiprotozoal Agents

Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...
Dosage Regimen: Fixed Dose01:01

Dosage Regimen: Fixed Dose

Fixed-dose regimens are a common approach to administer drugs to achieve and maintain desired levels of the drug in the body. In this dosing strategy, a specific amount of medication is given at regular intervals, often multiple times a day, to ensure a consistent drug concentration in the bloodstream.
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Giardiasis01:12

Giardiasis

Giardiasis is a globally prevalent intestinal infection caused by the protozoan parasite Giardia duodenalis (also known as G. lamblia or G. intestinalis). This flagellated protozoan is the most frequently identified intestinal parasite in the United States and worldwide. Transmission primarily occurs via the fecal-oral route, with infection arising from ingestion of water or food contaminated with cysts. Individuals in low-resource settings, international travelers, outdoor enthusiasts, daycare...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Smallpox01:24

Smallpox

Smallpox is a severe contagious disease caused by the Variola major virus, a double-stranded DNA member of the Poxviridae family.Variola major transmission occurs primarily via inhalation of virus-laden droplets or direct contact with infectious scabs. The incubation period averages approximately seven days, although it may range from 7 to 17 days depending on the inoculum and host factors.Clinically, the prodromal phase is marked by an abrupt onset of high fever, malaise, headache, and myalgia.

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Related Experiment Video

Updated: Jul 9, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Ivermectin: 25 years and still going strong.

S Omura1

  • 1The Kitasato Institute, Tokyo, Japan. omura-s@kitasato.or.jp

International Journal of Antimicrobial Agents
|November 27, 2007
PubMed
Summary

Ivermectin, a versatile drug, has significantly improved global health for billions since its 1987 human registration. It combats devastating tropical diseases and offers ongoing therapeutic benefits.

Area of Science:

  • * Tropical medicine
  • * Parasitology
  • * Drug discovery

Background:

  • * Ivermectin, initially for veterinary use, was approved for human treatment in 1987.
  • * It is recognized as a major global health intervention.
  • * The drug impacts billions of humans, livestock, and pets worldwide.

Purpose of the Study:

  • * To highlight the significance of Ivermectin in global health.
  • * To underscore its role in combating tropical diseases.
  • * To explore its broad-ranging applications and benefits.

Main Methods:

  • * Review of Ivermectin's historical development and market introduction.
  • * Analysis of its impact on human and animal health outcomes.
  • * Examination of its therapeutic applications, particularly in tropical regions.

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Last Updated: Jul 9, 2026

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians
06:49

Reduced Itraconazole Concentration and Durations Are Successful in Treating Batrachochytrium dendrobatidis Infection in Amphibians

Published on: March 14, 2014

Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates
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Measuring Caenorhabditis elegans Life Span in 96 Well Microtiter Plates

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Measuring Caenorhabditis elegans Life Span on Solid Media
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Main Results:

  • * Ivermectin has demonstrably improved the lives and productivity of billions.
  • * It plays a crucial role in controlling and potentially eradicating specific tropical diseases.
  • * Continuous discovery of new therapeutic uses expands its impact.

Conclusions:

  • * Ivermectin is a highly effective and versatile antiparasitic medication.
  • * Its widespread use represents a significant advancement in public health, particularly in resource-limited settings.
  • * Ongoing research promises further expansion of Ivermectin's beneficial applications.