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Related Concept Videos

Antifungal Agents01:15

Antifungal Agents

Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...

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Related Experiment Video

Updated: Jul 9, 2026

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans
04:48

Rose Bengal-Mediated Photodynamic Therapy to Inhibit Candida albicans

Published on: March 24, 2022

Antifungal photodynamic therapy.

Ryan F Donnelly1, Paul A McCarron, Michael M Tunney

  • 1School of Pharmacy, Queen's University Belfast, Medical Biology Centre, Belfast, UK. r.donnelly@qub.ac.uk

Microbiological Research
|November 27, 2007
PubMed
Summary

Photodynamic antimicrobial chemotherapy (PACT) offers a potent, selective method for destroying fungi. This approach uses light and photosensitizers, showing promise as an alternative to traditional antifungal treatments.

Area of Science:

  • Photodynamic antimicrobial chemotherapy (PACT)
  • Antifungal research
  • Microbial destruction

Background:

  • PACT utilizes photosensitizing drugs and visible light to selectively kill microbial cells.
  • Interest in PACT has surged due to the rise of antibiotic-resistant pathogens.
  • PACT has demonstrated in vitro efficacy against various microorganisms, including fungi.

Purpose of the Study:

  • To review existing studies on the antifungal applications of PACT.
  • To highlight PACT's potential as an alternative treatment for fungal infections.
  • To raise awareness of PACT research in combating fungal pathogens.

Main Methods:

  • Review of published studies on PACT's antifungal applications.
  • Analysis of experimental data on photodynamic action against fungi.

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  • Examination of photosensitizers like phenothiazinium, porphyrin, and phthalocyanine.

    • Main Results:

    • PACT effectively kills dermatomycetes and yeasts using specific photosensitizers.
    • Demonstrated high selectivity for fungal cells over human cells.
    • No reported cases of fungal resistance or genotoxic/mutagenic effects observed.

    Conclusions:

    • PACT shows significant potential for treating fungal infections.
    • Further in vivo studies are needed to translate in vitro success to clinical applications.
    • PACT represents a promising, non-toxic alternative in antifungal therapy.