Related Experiment Video
Updated: Jul 9, 2026

Measurement of Protein Import Capacity of Skeletal Muscle Mitochondria
Published on: January 7, 2022
The heterotrimeric [corrected] G protein subunit G alpha i is present on mitochondria
John S Lyssand1, Sandra M Bajjalieh
1Department of Pharmacology, University of Washington Seattle, Box 357750, WA, USA.
Abstract:
Receptors that signal through heterotrimeric [corrected] GTP binding (G) proteins mediate the majority of intercellular communication. Recent evidence suggests that receptors acting through G proteins also transfer signals across the nuclear membrane. Here we present cell fractionation and immunolabeling data showing that the heterotrimeric [corrected] G protein subunit Galphai is associated with mitochondria. This finding suggests that G protein receptor signaling may be a feature common to all membranes.
Related Concept Videos
Activation and Inactivation of G Proteins
Mitochondrial Protein Sorting
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
G-protein Coupled Receptors
G-protein Coupled Receptors
Translocation of Proteins into the Mitochondria
Sorting of outer membrane proteins:
Mitochondrial outer membrane proteins are of two types: the transmembrane, beta-barrel porins, and the membrane-anchored, alpha-helical proteins. Beta-barrel porin precursors are translocated by the TOM complex and inserted into the outer mitochondrial membrane by the SAM complex. In contrast,...
GTPases and their Regulation
Large G-proteins, also known...

