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Updated: Jul 9, 2026

Deciphering the Molecular Mechanism and Function of Pore-Forming Toxins Using Leishmania major
Published on: October 28, 2022
Comparative codon and amino acid composition analysis of Tritryps-conspicuous features of Leishmania major
Ipsita Chanda1, Archana Pan, Sanjoy Kumar Saha
1Department of Structural Biology and Bioinformatics, Indian Institute of Chemical Biology, Kolkata 700 032, India. ipsita_chanda@yahoo.co.in
Abstract:
Comparative analyses of codon/amino acid usage in Leishmania major, Trypanosoma brucei and Trypanosoma cruzi reveal that gene expressivity and GC-bias play key roles in shaping the gene composition of all three parasites, and protein composition of L. major only. In T. brucei and T. cruzi, the major contributors to the variation in protein composition are hydropathy and/or aromaticity. Principle of Cost Minimization is followed by T. brucei, disregarded by T. cruzi and opposed by L. major. Slowly evolving highly expressed gene-products of L. major bear signatures of relatively AT-rich ancestor, while faster evolution under GC-bias has characterized the lowly expressed genes of the species by higher GC12-content.
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