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[Pharmacological action on antiviral resistance in patients with acute pneumonia]
Abstract:
A study of 30 patients suffering of acute pneumonia indicates that the development of acute pneumonia occurs against the background of disorders of the functional activity of monocytes with prevalent reduction of the functional activity of phagocytosis and inhibition of the unspecific cellular antiviral resistance. Leucocytic interferon sharply activates phagocytosis. The number of phagocytic cells and activity of phagocytosis reduced and the number of virus-involved immunocompetent cells increased under the effect of antibiotics.
Insights
Acute pneumonia is linked to reduced monocyte function, impacting phagocytosis and antiviral resistance. Leucocytic interferon boosts phagocytosis, while antibiotics may decrease it and increase virus-involved cells.
Area of Science:
- Immunology
- Infectious Diseases
- Cell Biology
Background:
- Acute pneumonia development is associated with impaired monocyte functional activity.
- This impairment includes reduced phagocytic capacity and inhibited cellular antiviral resistance.
Purpose of the Study:
- To investigate the role of monocyte functional activity in acute pneumonia.
- To evaluate the effects of leucocytic interferon and antibiotics on immune responses in pneumonia patients.
Main Methods:
- Study involved 30 patients diagnosed with acute pneumonia.
- Monocyte functional activity, phagocytosis, and antiviral resistance were assessed.
- Effects of leucocytic interferon and antibiotic treatment on these parameters were observed.
Main Results:
- Reduced functional activity of monocytes, particularly phagocytosis, was observed in acute pneumonia.
- Unspecific cellular antiviral resistance was also inhibited.
- Leucocytic interferon demonstrated a significant activation of phagocytosis.
- Antibiotic treatment led to a decrease in phagocytic cells and activity, and an increase in virus-involved immunocompetent cells.
Conclusions:
- Disorders in monocyte functional activity, including phagocytosis and antiviral resistance, are central to acute pneumonia pathogenesis.
- Leucocytic interferon shows potential in enhancing phagocytic activity.
- Antibiotics may negatively impact cellular immune responses in pneumonia, warranting further investigation.