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Impaired left ventricular systolic synchronicity in hypertensive patients with ventricular arrhythmias

Hong-Wei Tan1, Li Li, Zhi-Hao Wang

  • 1Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Jinan, PR China.

Hypertension Research : Official Journal of the Japanese Society of Hypertension
|November 27, 2007
PubMed

Insights

Hypertension impairs left ventricular (LV) systolic synchronicity. Ventricular arrhythmias in hypertensive patients further worsen LV synchronicity, as detected by Tissue Doppler imaging (TDI).

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Cardiovascular Imaging

Background:

  • Left ventricular (LV) systolic synchronicity is often impaired in hypertensive patients.
  • Ventricular arrhythmias are common in hypertension and negatively affect cardiac function.
  • The specific impact of ventricular arrhythmias on LV synchronicity in hypertension remains unclear.

Purpose of the Study:

  • To investigate the influence of ventricular arrhythmias on LV synchronicity in hypertensive patients.
  • To assess the utility of Tissue Doppler imaging (TDI) in detecting these myocardial abnormalities.

Main Methods:

  • Tissue Doppler imaging (TDI) was performed on 136 subjects.
  • Subjects were divided into three groups: hypertensives without arrhythmias (n=74), hypertensives with ventricular arrhythmias (n=30), and normal controls (n=32).
  • LV synchronicity was evaluated using time to peak systolic contraction (T(s)) and early diastolic relaxation (T(e)) differences and standard deviations across LV segments.

Main Results:

  • LV systolic synchronicity was significantly impaired in hypertensive patients with ventricular arrhythmias (Group 2) compared to hypertensives without arrhythmias (Group 1) and controls.
  • Specifically, T(s)-max and T(s)-SD were significantly prolonged in Group 2.
  • TDI demonstrated its usefulness in detecting myocardial abnormalities in this patient group.

Conclusions:

  • Ventricular arrhythmias exacerbate the impairment of LV systolic synchronicity in hypertensive patients.
  • TDI is a valuable tool for identifying these cardiac functional changes.

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