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Updated: Jul 9, 2026

Assessment of Memory Function in Pilocarpine-induced Epileptic Mice
Published on: June 4, 2020
Recognition memory: opposite effects of hippocampal damage on recollection and familiarity
Magdalena M Sauvage1, Norbert J Fortin, Cullen B Owens
1Center for Memory and Brain, Boston University, Boston, MA 02215, USA.
Abstract:
A major controversy in memory research concerns whether recognition is subdivided into distinct cognitive mechanisms of recollection and familiarity that are supported by different neural substrates. Here we developed a new associative recognition protocol for rats that enabled us to show that recollection is reduced, whereas familiarity is increased following hippocampal damage. These results provide strong evidence that these processes are qualitatively different and that the hippocampus supports recollection and not familiarity.
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