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Point-of-Care Kidney and Genitourinary Ultrasound in Adults: Image Acquisition
Published on: June 21, 2024
Imaging in unilateral Wilms tumour
Hervé J Brisse1, Anne M Smets, Sue C Kaste
1Service de Radiodiagnostic, Institut Curie, 26 Rue d'Ulm, Paris, France. herve.brisse@curie.net
Insights
Wilms tumour treatment varies globally, impacting imaging choices. This review details radiological techniques for diagnosing paediatric Wilms tumour and assessing metastatic disease.
Area of Science:
- Pediatric Oncology
- Radiology
- Medical Imaging
Background:
- Wilms tumour is a common childhood malignancy with a good prognosis.
- Treatment protocols for Wilms tumour differ significantly between Europe (chemotherapy then surgery) and the United States (surgery then chemotherapy).
- These geographical variations in treatment influence the selection and application of diagnostic imaging modalities.
Purpose of the Study:
- To discuss the role of various imaging modalities in the diagnosis of Wilms tumour.
- To compare the strengths and weaknesses of ultrasound (US), computed tomography (CT), and magnetic resonance imaging (MRI) in diagnosing Wilms tumour.
- To highlight the importance of imaging in treatment planning and detecting metastatic disease.
Main Methods:
- Review of current radiological techniques used for Wilms tumour diagnosis.
- Discussion of imaging protocols based on European (SIOP) and US (NWTS) treatment guidelines.
- Focus on imaging for pulmonary metastases and tumour rupture.
Main Results:
- Imaging, alongside clinical assessment, aids in predicting Wilms tumour.
- Preoperative image-guided biopsy is crucial in the UK to differentiate Wilms tumour from other neoplasms.
- Imaging provides essential anatomical detail for surgical planning in the US protocol.
- CT is used to detect pulmonary nodules, and tumour rupture at diagnosis is assessed radiologically.
Conclusions:
- The choice of imaging modality for Wilms tumour diagnosis is influenced by geographical treatment protocols.
- Accurate radiological assessment is vital for appropriate treatment selection, surgical planning, and monitoring metastatic disease.
- Understanding the nuances of imaging techniques is critical for optimizing patient outcomes in Wilms tumour management.
Abstract:
Wilms tumour is one of the most common malignancies in children, with an excellent prognosis after therapy. There is a very diverse approach to treatment according to geographical location. This variation in therapeutic attitude toward Wilms tumour, particularly between the United States and Europe, has consequences for the choice of imaging modality at diagnosis. In Europe, the International Society of Paediatric Oncology (SIOP) treatment protocol is based on chemotherapy followed by surgery. Imaging (US, CT and MRI), clinical history and examination will help predict whether the findings are consistent with Wilms tumour. Furthermore, in the UK preoperative image-guided biopsy is advised to help identify the small group of patients who, despite typical imaging features of Wilms tumour, have other types of neoplasia that require alternative management. In the United States, the National Wilms Tumor Study (NWTS) advises surgery prior to chemo- and radiotherapy. Hence imaging must provide detailed anatomical information for surgical planning. This article discusses the role of imaging at diagnosis and the relative strengths and weaknesses of the available radiological techniques. We also focus on imaging the lung for metastatic disease and the consequences (to the patient's ultimate outcome) of CT-diagnosed small pulmonary nodules and discuss the radiological diagnosis and consequences of tumour rupture present at diagnosis.
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