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Published on: January 28, 2020

Coronary heart disease in diabetics: prognostic implications and results of interventions

Per Mølstad1

  • 1Feiring Heart Clinic, Feiring, Norway. moelsta@online.no

Scandinavian Cardiovascular Journal : SCJ
|November 27, 2007
PubMed

Insights

Diabetics with coronary artery disease face more severe disease and lower survival rates. Diabetes mellitus is a significant risk factor for death, particularly in smokers not treated with coronary artery bypass grafting.

Area of Science:

  • Cardiology
  • Diabetology
  • Public Health

Background:

  • Diabetes mellitus is a growing global health concern.
  • Diabetic patients often present with more complex cardiovascular conditions.
  • Understanding survival differences in diabetic vs. non-diabetic patients with coronary disease is crucial.

Purpose of the Study:

  • To compare the extent of coronary artery disease (CAD) in diabetic and non-diabetic individuals.
  • To analyze and compare subsequent survival rates between these two groups.
  • To identify risk factors influencing mortality in diabetic patients with CAD.

Main Methods:

  • Retrospective analysis of 13,511 patients undergoing coronary angiography (March 1999-December 2005).
  • Identification of 1,475 diabetic patients within the cohort.
  • Survival status ascertained via the Norwegian National Registry up to May 2006.

Main Results:

  • Diabetic patients exhibited more severe CAD (over 40% with three-vessel disease) and were more symptomatic.
  • Unadjusted survival rates were lower in the diabetic group.
  • Cox regression analysis confirmed diabetes mellitus as a risk factor (HR 1.33), with higher mortality in smoking diabetics.

Conclusions:

  • Diabetics present with more advanced coronary artery disease at the time of diagnosis.
  • Diabetes mellitus remains a significant predictor of mortality, especially in smokers, except for those treated with coronary artery bypass grafting (CABG).
Abstract

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