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Updated: Jul 9, 2026

A Bioluminescent and Fluorescent Orthotopic Syngeneic Murine Model of Androgen-dependent and Castration-resistant Prostate Cancer
Published on: March 6, 2018
[Correction of androgen deficiency in elderly patients]
Abstract:
In spite of its prevalence, age-related androgen deficiency has not been studied in full. Androgen deficiency is associated with a lot of age-related diseases (coronary artery disease, arterial hypertension, obesity, diabetes mellitus, osteoporosis etc). The level of testosterone in men gradually decreases beginning at the age of 30 to 40 years. Age-related hypogonadism results in an increase in the frequency of cardiovascular diseases and cardiovascular mortality. Low testosterone level is associated with dyslipidemia, atherosclerosis, reduction of fibrinolysis, insulinoresistance, and abdominal obesity. Physiological doses of androgen preparations are supposed to have a positive effect on various chains of metabolism and improve the course of diseases in men.
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