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[Menopausal changes in circadian heart rate variability].

Agata Ryś¹, Andrzej Ryś, Piotr Kogut

¹Katedra Patofizologii, Collegium Medicum Unwersytetu Jagielloriskiego, Kraków.

Folia Medica Cracoviensia

|November 28, 2007

Summary

Menopause is associated with decreased heart rate variability (HRV) and impaired cardiac autonomic nervous system (cANS) regulation. Postmenopausal women show reduced parasympathetic activity, indicating potential cardiovascular risks.

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Area of Science:

Cardiology
Autonomic Nervous System Research
Women's Health

Background:

Cardiovascular symptoms are often observed during perimenopause.
These symptoms may be linked to a decline in cardiac autonomic nervous system (cANS) function.
Menopause-induced hormonal changes can impact cardiovascular regulation.

Purpose of the Study:

To investigate the effect of menopause on circadian heart rate variability (HRV).
To assess changes in autonomic nervous system activity between premenopausal and postmenopausal women.
To identify potential cardiovascular regulatory differences related to menopausal status.

Main Methods:

The study included 42 healthy women, divided into premenopausal and postmenopausal groups.
Menopausal status was confirmed using plasma estradiol and FSH levels.
Twenty-four-hour ambulatory ECG recordings were analyzed for HRV parameters during daytime and nighttime periods.

Main Results:

Premenopausal women exhibited higher daytime HRV parameters (SDNN, pNN50, nLF) compared to postmenopausal women.
Postmenopausal women showed higher daytime nHF, suggesting altered autonomic balance.
Both groups displayed distinct nighttime HRV patterns, with premenopausal women having higher pNN50 and nLF, and postmenopausal women having higher nHF.

Conclusions:

Reduced time-domain HRV parameters in postmenopausal women suggest diminished parasympathetic heart regulation.
Lower nLF values in postmenopausal women may indicate impaired arterial baroreceptor reflex function.
The observed increase in nHF warrants further investigation to understand its implications.