When should trastuzumab be stopped after achieving complete response in HER2-positive metastatic breast cancer
Manuela Beda1, Umberto Basso, Cristina Ghiotto
1Department of Medical Oncology, Istituto Oncologico Veneto-IOV, Padua, Italy. m.beda@libero.it
Tumori
|November 28, 2007
Abstract:
We report the case of a woman with HER2-positive metastatic breast cancer who achieved prolonged complete remission of multiple liver metastases after treatment with weekly trastuzumab plus paclitaxel but relapsed in the brain soon after stopping trastuzumab maintenance therapy which had been prosecuted for almost three years. In the absence of randomized trials, the optimal duration of trastuzumab administration after achieving complete remission of metastatic breast cancer remains questionable.
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