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Updated: Jul 9, 2026

Modifying Levels of Maternal Dietary Folic Acid or Choline to Study the Impact of Deficiencies on Offspring Health Outcomes
Published on: June 28, 2024
Food fortification with folic acid: has the other shoe dropped?
1Center for Studies of Sensory Impairment, Aging, and Metabolism, Guatemala City, Guatemala. cessiam@guate.net.gt
Abstract:
Folic acid (FA) supplementation effectively reduces the rates of children born with neural tube defects (NTDs). Currently, 42 nations practice mandatory FA fortification to combat NTD. In addition to NTD, FA fortification may also have salutary effects on the incidence of orofacial cleft birth defects and have secondary benefits in reducing serum homocysteine concentrations and stroke mortality. However, a recent note of caution has been raised concerning a possible negative effect of mandatory FA fortification on the incidence of colorectal cancer.
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