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Palmar erythema.

Rocco Serrao1, Matthew Zirwas, Joseph C English

  • 1Department of Dermatology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

American Journal of Clinical Dermatology
|November 28, 2007
PubMed
Summary
This summary is machine-generated.

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Palmar erythema (PE) is a skin finding linked to various health conditions, including pregnancy, liver disease, and arthritis. Identifying the cause is key, as treatment focuses on the underlying disorder.

Area of Science:

  • Dermatology
  • Internal Medicine
  • Pathophysiology

Background:

  • Palmar erythema (PE) is a physical finding with diverse etiologies, ranging from physiological states to systemic diseases.
  • It can be a primary finding or a secondary marker of underlying pathology, necessitating careful clinical evaluation.
  • Existing literature presents numerous causes of PE, but a structured approach for clinicians is lacking.

Purpose of the Study:

  • To review the current literature on the causes of palmar erythema.
  • To provide a framework to guide clinicians in diagnosing the etiology of PE.
  • To highlight PE as a potential indicator of various systemic conditions.

Main Methods:

  • Comprehensive review of existing medical literature.
  • Synthesis of information regarding the association of PE with different physiological and pathological states.

Related Experiment Videos

  • Categorization of PE causes into primary/physiologic and secondary/pathologic.

    • Main Results:

    • Palmar erythema is associated with pregnancy (30%), liver cirrhosis (23%), rheumatoid arthritis (>60%), thyrotoxicosis (18%), and diabetes mellitus (4.1%).
    • Other causes include rare neonatal liver diseases, syphilis, HTLV-1, drug-induced reactions, brain neoplasms, and environmental factors like smoking and mercury poisoning.
    • PE can mimic other conditions like erythema ab igne and is more prevalent in individuals with atopic diathesis.

    Conclusions:

    • Palmar erythema is a significant clinical sign with a broad spectrum of underlying causes.
    • Diagnosis requires a systematic approach to identify primary or secondary etiologies.
    • Treatment should target the identified underlying condition, as primary PE requires no specific intervention.