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Updated: Jul 9, 2026

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration
14:14

In vitro Coculture Assay to Assess Pathogen Induced Neutrophil Trans-epithelial Migration

Published on: January 6, 2014

Pathobiology of neutrophil transepithelial migration: implications in mediating epithelial injury

Alex C Chin1, Charles A Parkos

  • 1Epithelial Pathobiology Unit, Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia 30322, USA. achin@emory.edu

Annual Review of Pathology
|November 28, 2007
PubMed

Insights

Neutrophil (polymorphonuclear leukocyte, PMN) migration into tissues is key in inflammatory diseases. Understanding PMN-epithelial interactions offers new therapeutic targets for inflammation.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Background:

  • Neutrophil (polymorphonuclear leukocyte, PMN) transepithelial migration and accumulation are characteristic of inflammatory conditions.
  • This process is directly linked to clinical disease severity and epithelial damage.

Purpose of the Study:

  • To review the consequences of PMN infiltration into epithelial tissues.
  • To highlight molecular mechanisms of PMN epithelial interactions during transmigration.

Main Methods:

  • Literature review of existing research on neutrophil transmigration.
  • Analysis of molecular interactions between neutrophils and epithelial cells.

Main Results:

  • PMN infiltration contributes significantly to epithelial tissue injury during inflammation.
  • Specific molecular pathways govern PMN adhesion, transmigration, and subsequent tissue effects.

Conclusions:

  • A comprehensive understanding of PMN-epithelial interactions is crucial for developing targeted anti-inflammatory therapies.
  • Further research into these mechanisms may lead to organ-specific treatments to mitigate epithelial inflammation.

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