Related Experiment Video
Updated: Jul 9, 2026

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
Published on: September 15, 2017
The endothelium as a target for infections
Gustavo Valbuena1, David H Walker
1School of Medicine, Universidad de Los Andes, Bogota, Colombia. gvalbuen@utmb.edu
Abstract:
The endothelial cells lining vascular and lymphatic vessels are targets of several infectious agents, including viruses and bacteria, that lead to dramatic changes in their functions. Understanding the pathophysiological mechanisms that cause the clinical manifestations of those infections has been advanced through the use of animal models and in vitro systems; however, there are also abundant studies that explore the consequences of endothelial infection in vitro without supporting evidence that endothelial cells are actual in vivo targets of infection in human diseases. This article defines criteria for considering an infection as truly endothelium-targeted and reviews the literature that offers insights into the pathogenesis of human endothelial-target infections.
More Related Videos
Related Concept Videos
Overview of the Vascular System
Adherens Junctions
Adherens Junctions are Dynamic
The endothelial cells...
Endocarditis I: Introduction
Inflammation
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Selectins

