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Related Experiment Videos

The aging brain.

Bruce A Yankner1, Tao Lu, Patrick Loerch

  • 1Department of Pathology, Harvard Medical School, Boston, MA 02115, USA. bruce_yankner@hms.harvard.edu

Annual Review of Pathology
|November 28, 2007
PubMed
Summary
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Brain aging causes cognitive decline and increases Alzheimer's risk. This review integrates aging mechanisms with neurodegeneration, exploring the transition from normal to pathological brain aging and toxic protein roles.

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Gerontology

Background:

  • Cognitive decline is common with aging, a primary risk factor for Alzheimer's disease and other neurodegenerative disorders.
  • The molecular mechanisms underlying brain aging and its transition to pathological states remain poorly understood.
  • Toxic protein aggregates like amyloid beta, tau, and alpha-synuclein are implicated in neurodegenerative diseases.

Purpose of the Study:

  • To integrate current knowledge of age-related cognitive and neuroanatomical changes with molecular mechanisms of aging.
  • To explore the transition from normal brain aging to pathological aging and neurodegenerative disorders.
  • To discuss unifying systems biology of the aging brain with neurodegeneration pathogenesis.

Main Methods:

Related Experiment Videos

  • Literature review integrating studies on brain aging, cognitive decline, and molecular mechanisms.
  • Analysis of toxic protein aggregates (amyloid beta, tau, alpha-synuclein) in neurodegenerative disease models.
  • Discussion of systems biology approaches to understand the aging brain and neurodegeneration.

    • Main Results:

    • Aging significantly impacts cognitive function and brain structure.
    • The precise molecular pathways linking normal aging to neurodegenerative diseases are not fully elucidated.
    • Current models do not fully explain sporadic disease origins or the aging-disease nexus.

    Conclusions:

    • Understanding the molecular basis of brain aging is crucial for addressing neurodegenerative diseases.
    • Further research is needed to bridge the gap between aging processes and the pathogenesis of conditions like Alzheimer's and Parkinson's disease.
    • A systems biology approach may offer a unified framework for studying brain aging and neurodegeneration.