Related Experiment Video
Updated: Jul 9, 2026

Mouse Kidney Transplantation: Models of Allograft Rejection
Published on: October 11, 2014
Kidney transplantation: mechanisms of rejection and acceptance
Lynn D Cornell1, R Neal Smith, Robert B Colvin
1Department of Pathology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. cornell.lynn@mayo.edu
Abstract:
We describe the molecular and cellular mechanisms believed to be responsible for the rejection of renal allografts, including acute T cell-mediated rejection, acute antibody-mediated (humoral) rejection, rejection mediated by the innate immune system, and chronic rejection. We present mechanisms of graft acceptance, including accommodation, regulation, and tolerance. Studies in animals have replicated many pathologic features of acute and chronic rejection. We illuminate the pathogenesis of human pathology by reflection from experimental models.
Related Concept Videos
Kidney Transplant II: Surgical Procedure
Kidney Transplant I: Introduction
Kidney Transplant III: Nursing Management
Tissue Transplantation
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
Cell-mediated Immune Responses
Bone Marrow Sampling and Transplants
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy the...
