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Related Concept Videos

Traumatic Brain Injury l: Introduction01:28

Traumatic Brain Injury l: Introduction

DefinitionTraumatic brain injury, or TBI, is a disturbance of normal brain function induced by an external mechanical force, such as a direct blow to the head or a penetrating injury. It can affect both brain structure and function, producing a wide range of clinical outcomes. TBI is a heterogeneous condition, meaning its effects may differ based on the type, location, and severity of the injury.Basis of ClassificationTBI is classified based on severity, injury mechanism, or pathophysiology. In...

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Related Experiment Video

Updated: Jul 9, 2026

Advanced Diffusion Imaging in The Hippocampus of Rats with Mild Traumatic Brain Injury
10:33

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Published on: August 14, 2019

White matter abnormalities in mild traumatic brain injury: a diffusion tensor imaging study.

D R Rutgers1, F Toulgoat, J Cazejust

  • 1Department of Neuroradiology, Centre Hospitalo-Universitaire de Bicêtre, Bicêtre, France.

AJNR. American Journal of Neuroradiology
|November 28, 2007
PubMed
Summary

Mild traumatic brain injury (TBI) is linked to widespread white matter abnormalities, including reduced fractional anisotropy (FA) in various brain regions. Fiber tracking reveals disruption in a minority of these affected white matter tracts.

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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
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Development of an Uncomplicated Mild Traumatic Brain Injury Model Modified by Weight-Drop Method and Evidenced by Magnetic Resonance Imaging
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Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases
09:33

Diffusion Tensor Magnetic Resonance Imaging in the Analysis of Neurodegenerative Diseases

Published on: July 28, 2013

Area of Science:

  • Neuroimaging
  • Neurology
  • Radiology

Background:

  • Traumatic axonal injury is a key brain abnormality in head trauma.
  • Reduced fractional anisotropy (FA) on diffusion tensor imaging (DTI) characterizes these injuries.

Purpose of the Study:

  • To investigate the extent and location of white matter abnormalities in mild TBI patients.
  • To assess fiber disruption using fiber tracking in affected white matter regions.

Main Methods:

  • Diffusion tensor imaging (DTI) and voxel-based analysis were used to compare 21 mild TBI patients with 11 control subjects.
  • Regions of reduced FA were identified, and their characteristics, including fiber continuity, were analyzed.

Main Results:

  • Mild TBI patients exhibited an average of 9.1 regions with reduced FA, primarily in supratentorial white matter, cingulum, and corpus callosum.
  • Affected areas mainly involved projection, callosal, and association fiber bundles; internal capsules and infratentorial white matter were less affected.
  • Fiber tracking showed discontinuity in 19.3% of the affected fiber bundles.

Conclusions:

  • Mild TBI is associated with widespread white matter abnormalities, indicated by reduced FA in multiple brain locations.
  • While many fiber bundles are affected, only a subset demonstrates discontinuity on fiber tracking.