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Updated: Jul 9, 2026

In Vivo Functional Study of Disease-associated Rare Human Variants Using Drosophila
Published on: August 20, 2019
Drosophila biology in the genomic age
Therese Ann Markow1, Patrick M O'Grady
1Division of Organisms and the Environment, University of California, Berkeley, California 9472, USA. tmarkow@arl.arizona.edu
Abstract:
Over the course of the past century, flies in the family Drosophilidae have been important models for understanding genetic, developmental, cellular, ecological, and evolutionary processes. Full genome sequences from a total of 12 species promise to extend this work by facilitating comparative studies of gene expression, of molecules such as proteins, of developmental mechanisms, and of ecological adaptation. Here we review basic biological and ecological information of the species whose genomes have recently been completely sequenced in the context of current research.

