Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Toxoplasmosis01:28

Toxoplasmosis

Toxoplasmosis, a zoonotic disease caused by the protozoan Toxoplasma gondii, poses significant public health challenges globally due to its high seroprevalence and varied clinical manifestations. As an obligate intracellular parasite, T. gondii can infect all warm-blooded vertebrates, but felids are its only definitive hosts, shedding unsporulated oocysts into the environment. Humans typically acquire the infection through ingestion of tissue cysts in undercooked meat or oocysts from...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
Rabies01:28

Rabies

Rabies is a lethal zoonotic disease caused by a single-stranded, negative-sense RNA virus of the Lyssavirus genus, within the family Rhabdoviridae. Its primary mode of transmission to humans is through bites or saliva-contaminated scratches from infected mammals such as dogs, bats, raccoons, or foxes. Transmission can also occur if infectious saliva contacts abraded skin or intact mucous membranes, including the conjunctiva.Viral Entry and Early ReplicationOnce introduced at the bite or scratch...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Improving sensitivity and selectivity of human ACTH[1-39] quantitation using online size exclusion chromatography and antibody-free LC-HRMS.

Bioanalysis·2025
Same author

Can drug-induced aseptic meningitis account for some cases of eosinophilic meningitis/meningoencephalitis in dogs?

New Zealand veterinary journal·2021
Same author

Animal medical genetics: a historical perspective on more than 50 years of research into genetic disorders of animals at Massey University.

New Zealand veterinary journal·2021
Same author

First case of a dog infected with <i>Aspergillus (Phialosimplex) caninus</i> in Australasia.

New Zealand veterinary journal·2019
Same author

Corticosterone and serotonin similarly influence GABAergic and purinergic pathways to affect cortical inhibitory networks.

Journal of neuroendocrinology·2018
Same author

Sex differences in the early life correlates of natural antibody concentrations.

Journal of developmental origins of health and disease·2015

Related Experiment Video

Updated: Jul 9, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

Leukoencephalomyelopathy in specific pathogen-free cats.

J P Cassidy1, C Caulfield, B R Jones

  • 1Veterinary Sciences Centre, School of Food Science, Agriculture and Veterinary Medicine, University College Dublin, Belfield, Dublin 4, Ireland. Joseph.Cassidy@ucd.ie

Veterinary Pathology
|November 28, 2007
PubMed
Summary

Feline leukoencephalomyelopathy caused progressive hind limb ataxia in cats. Investigations suggest a link between this neurological condition and gamma-irradiated diets with reduced vitamin A.

More Related Videos

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Related Experiment Videos

Last Updated: Jul 9, 2026

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines
09:46

Rat Model of Widespread Cerebral Cortical Demyelination Induced by an Intracerebral Injection of Pro-Inflammatory Cytokines

Published on: September 21, 2021

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
26:48

Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis

Published on: July 4, 2007

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis
06:19

Induction and Diverse Assessment Indicators of Experimental Autoimmune Encephalomyelitis

Published on: September 9, 2022

Area of Science:

  • Veterinary Neurology
  • Pathology
  • Animal Nutrition

Background:

  • Progressive hind limb ataxia outbreaks occurred in a cat colony.
  • 190 of 540 at-risk cats exhibited clinical signs.

Purpose of the Study:

  • To investigate the clinicopathologic features of feline leukoencephalomyelopathy.
  • To explore potential etiologies for the observed neurological syndrome.

Main Methods:

  • Histopathologic examination of spinal cord and brain tissues from affected cats.
  • Clinical assessment of affected animals within the colony.

Main Results:

  • Identified moderate to severe bilateral axonal degeneration in multiple central nervous system white matter regions.
  • Observed accompanying microgliosis, astrocytosis, and capillary hyperplasia.
  • Circumstantial evidence linked neuronal lesions to gamma-irradiated diets with reduced vitamin A.

Conclusions:

  • The clinicopathologic syndrome is termed feline leukoencephalomyelopathy.
  • Degenerative lesions suggest nutritional, metabolic, or toxic causes.
  • Further analysis is needed to confirm the role of diet in the etiology.