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Splenic inflammatory pseudotumor (inflammatory myofibroblastic tumor)
Hisashi Oshiro1, Masato Nomura, Shoji Yamanaka
1Division of Anatomic and Surgical Pathology, Yokohama City University Hospital.
Journal of Clinical and Experimental Hematopathology : JCEH
|November 28, 2007
Summary
A rare splenic inflammatory pseudotumor was diagnosed in a man with chronic bronchitis and sleep apnea. Surgical removal led to the resolution of his other conditions and no recurrence of the tumor.
Area of Science:
- Pathology
- Oncology
- Immunology
Background:
- A 43-year-old male patient with a history of chronic bronchitis and sleep apnea syndrome presented with a screen-detected splenic mass.
- Differential diagnoses included splenic hamartoma, hemangioma, lymphoma, and angiosarcoma.
Observation:
- Imaging revealed a 7 cm solitary splenic lesion.
- Histopathology showed fibroblastic/myofibroblastic spindle cell proliferation with inflammatory infiltrate.
- Immunohistochemistry and in situ hybridization ruled out infectious and neoplastic etiologies like Epstein-Barr virus.
Findings:
- The splenic lesion was identified as an inflammatory pseudotumor (myofibroblastic tumor).
- The patient underwent splenectomy with an uneventful postoperative course and no recurrence at 22 months.
- Spontaneous resolution of chronic bronchitis and sleep apnea syndrome was observed post-splenectomy.
Implications:
- Splenic inflammatory pseudotumors are rare and can mimic other splenic lesions.
- Splenectomy can be curative for splenic inflammatory pseudotumors.
- The resolution of comorbid conditions post-splenectomy suggests a potential link, warranting further investigation.
