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A new trimethoprim resistance gene, dhfrX, in the In7 integron of plasmid pDGO100
Y Parsons1, R M Hall, H W Stokes
1School of Biological Sciences, Macquarie University, Sydney, NSW, Australia.
Antimicrobial Agents and Chemotherapy
|November 1, 1991
Abstract:
A new trimethoprim resistance determinant, designated dhfrX, was identified in the In7 integron of pDGO100. The sequence of the dhfrX dihydrofolate reductase is up to 28% identical to the sequences of several known dihydrofolate reductase proteins. The dhfrX gene is adjacent to the second 3'-conserved segment of the In7 integron, but the first 77 bases of this segment are not present.