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Nitrogranulogen-dependent inhibition of antibody synthesis. I. In vitro studies in man
M Wasik1, B Stepień-Sopniewska, A Kozakiewicz
1Department of Immunology, Medical School, Warsaw.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1991
Abstract:
Nitrogranulogen causes a comparable suppression of immunoglobulin synthesis by human lymphocytes in vitro as a standard alkylating agent, 4-hydro-peroxycyclophosphamide. Mixed lymphocyte culture reaction-elicited T and B cell responses are especially sensitive to the agent. The immunosuppressive activity of NTG is enhanced by a thymic hormone (TFX).