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Relationship between topological properties and biological activity of platinum (II) complexes
K Romanowska1, J Kuduk-Jaworska
1Institute of Chemistry, Wrocław University.
Archivum Immunologiae Et Therapiae Experimentalis
|January 1, 1991
Abstract:
A graph-theoretical method is applied to model of the relations between structure and biological activity of the anticancer Pt(II) complexes. Values of LD50, ID90, TI and % of ILS resulted from the treatment of animals bearing experimentalis ADJ/PC6 or L1210 tumors, available in the literature, were used as parameters characterizing the antitumor activity of platinum complexes. The results indicate that it is possible to find a topological description of these complexes which could be useful in their structure - activity investigations.