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Updated: Jul 9, 2026

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
Published on: September 12, 2016
Does inflammation in an autoimmune disease differ from inflammation in neurodegenerative diseases? Possible
Michal Schwartz1, Oleg Butovsky, Jonathan Kipnis
1Department of Neurobiology, The Weizmann Institute of Science, 76100, Rehovot, Israel. michal.schwartz@weizmann.ac.il
Abstract:
Accumulating evidence suggests that neurodegenerative diseases of the central nervous system (CNS) are associated with a local inflammatory response. CNS autoimmune diseases are also associated with inflammation. Does this mean that all neurodegenerative diseases are autoimmune in nature? Does it imply that autoimmune and neurodegenerative diseases are both eligible for the same therapy? What distinguishes between the two types of disease? Do they differ both in etiology and in pathology, or do they have different etiologies but similar pathology and progression? In this minireview we offer a new view of the inflammatory differences between neurodegenerative and autoimmune diseases in the CNS and discuss the implications for therapy.
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