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Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies
Allyn C Howlett1, Somnath Mukhopadhyay, Derek C Norford
1Neuroscience of Drug Abuse Research Program, 208 Julius L. Chambers Biomedical/Biotechnology Research Institute, North Carolina Central University, 700 George Street, Durham, NC 27707, USA. ahowlett@nccu.edu
Abstract:
Neuropathologies that affect our population include ischemic stroke and neurodegenerative diseases of immune origin, including multiple sclerosis. The endocannabinoid system in the brain, including agonists anandamide (arachidonyl ethanolamide) and 2-arachidonoylglycerol, and the CB1 and CB2 cannabinoid receptors, has been implicated in the pathophysiology of these disease states, and can be a target for therapeutic interventions. This review concentrates on cellular signal transduction pathways believed to be involved in the cellular damage.
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