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Updated: Jul 9, 2026

An Assay to Detect Protection of the Retinal Vasculature from Diabetes-Related Death in Mice
Published on: January 12, 2024
[HLA-A24: risk factor in proliferante diabetic retinopathy]
V M Asensio-Sánchez1, B Rodríguez-Delgado, E García-Herrero
1Hospital General, Medina del Campo, Valladolid, España. vasensio@hmdc.sacyl.es
Objective:
Proliferative diabetic retinopathy (PDR) is characterized by a progressive visual impairment in young people. Human leucocyte antigen (HLA)-A24 is a well-established factor associated with the pancreatic islets of Langerhans lost in this process. Our aim was to study further the relationship of the HLA-A24 associated with PDR.
Materials And Methods:
We evaluated a group of patients with PDR (n=95) and a healthy control group (n= 60). HLA-A24 for each participant in the study was determined by molecular hybridization techniques.
Results:
The control group showed a lower frequency of HLA-A24 compared with the PDR group (p = 0.043). HLA-A24 was associated with PDR (OR = 5.4; 95% CI= 3.2-7.6; p< 0.001).
Conclusions:
HLA-A24 is not a protective factor for PDR, but is a risk factor of its development.
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