Related Experiment Video

Updated: Jul 9, 2026

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches
13:36

Utilizing the Antigen Capsid-Incorporation Strategy for the Development of Adenovirus Serotype 5-Vectored Vaccine Approaches

Published on: May 6, 2015

A community-derived outbreak of adenovirus type 3 in children in Taiwan between 2004 and 2005

Sui-Yuan Chang1, Chun-Nan Lee, Pi-Han Lin

  • 1Department of Clinical Laboratory Sciences and Medical Biotechnology, National Taiwan University College of Medicine, Taipei, Taiwan.

Journal of Medical Virology
|November 28, 2007
PubMed

Insights

A 2004-2005 northern Taiwan outbreak of respiratory adenovirus was primarily caused by adenovirus type 3 (Ad3). This Ad3 strain was linked to more severe childhood infections, including bronchopneumonia.

Area of Science:

  • Pediatric Infectious Diseases
  • Virology
  • Epidemiology

Background:

  • Respiratory adenovirus infections are common in children.
  • Adenovirus outbreaks can cause significant pediatric morbidity.
  • Understanding circulating serotypes and their clinical impact is crucial for public health.

Purpose of the Study:

  • To identify the predominant adenovirus serotype during a 2004-2005 northern Taiwan outbreak.
  • To characterize the clinical severity and patient demographics associated with the outbreak.
  • To determine the specific genotype of the predominant adenovirus type.

Main Methods:

  • Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was used to serotype 172 adenovirus isolates.
  • Full-length genome RFLP was performed on 15 Ad3 isolates to determine genotype.
  • Clinical data from Ad3-infected patients were compared between the outbreak and baseline periods.

Main Results:

  • Adenovirus type 3 (Ad3) was the predominant serotype (87.2%) during the outbreak.
  • All analyzed Ad3 isolates belonged to genotype Ad3a2.
  • Severe infections (bronchopneumonia, exudative tonsillitis) were significantly higher during the outbreak (58.0% vs. 40.2%) and affected younger children.

Conclusions:

  • Adenovirus type 3 (Ad3), specifically genotype Ad3a2, was the primary cause of the 2004-2005 respiratory outbreak in northern Taiwan.
  • The Ad3 strain during the outbreak was associated with increased severity of illness in children.
  • Younger children were more susceptible to severe adenovirus infections during this outbreak.

More Related Videos

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors19:02

High-Efficiency Transduction of Liver Cancer Cells by Recombinant Adeno-Associated Virus Serotype 3 Vectors

Published on: March 22, 2011

Related Concept Videos

Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Diphtheria01:28

Diphtheria

Diphtheria is an acute, toxin-mediated infectious disease that primarily affects the upper respiratory tract. It is caused by Corynebacterium diphtheriae, a Gram-positive, pleomorphic rod that lacks spore-forming capability and exhibits a characteristic club-shaped morphology under microscopic examination. While C. diphtheriae can asymptomatically colonize mucosal surfaces, clinical disease manifests only when the bacterial strain is lysogenized by a specific β-corynephage. This phage...
Influenza01:27

Influenza

Influenza is an acute, highly communicable viral disease that affects the respiratory tract and is responsible for seasonal epidemics worldwide. Influenza A is the most prevalent type associated with widespread outbreaks and is subtyped based on two surface glycoproteins: hemagglutinin (H) and neuraminidase (N), as in H1N1. These glycoproteins are essential for viral infectivity, transmission, and immune recognition. Transmission occurs primarily through respiratory droplets and contaminated...
Chickenpox01:20

Chickenpox

Chickenpox is an acute, highly contagious disease caused by the varicella-zoster virus (VZV), a double-stranded DNA virus belonging to the Herpesviridae family. Its transmission occurs primarily through the inhalation of respiratory droplets or direct contact with vesicular fluid from skin lesions. The incubation period typically ranges from 10 to 21 days, during which the virus replicates and disseminates through sequential phases within the host. Although generally self-limiting in children,...